Fri Jul 04 2025

27 articles - From Friday Jun 27 2025 to Friday Jul 04 2025

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Inflamm Bowel Dis

Fecal Microbial Community Profiling Allows Discrimination of Phenweotype and Treatment Response in Pediatric Crohn's Disease and Ulcerative Colitis-An International Meta-Analysis.

Gut microbial community structure is substantially altered in active and inactive PIBD and may be utilized as a biomarker for differentiating PIBD subtype and predicting treatment response.

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Liver Transpl

Prognostic and diagnostic biomarkers in liver transplantation: A systematic review and meta-analysis.

Additionally, we identified novel combinations of biomarkers that exhibited prognostic value for LT patients. Finally, we demonstrate that combined analytical tools for assessing large clinical datasets effectively evaluate multi-modal markers for risk stratification of early and late outcomes for LT.

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Pancreas

Comparison of Biliary Drainage Techniques for MBO: A Meta-Analysis.

PTBD may offer advantages over EBD in managing MBO, including fewer complications and reduced incidence of pancreatitis, suggesting PTBD as a potentially safer and more effective treatment option. Nonetheless, further large-scale, high-quality studies are needed to validate these findings.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Effectiveness of regular oat β-glucan-enriched bread compared with whole-grain wheat bread on long-term glycemic control in adults at risk of type 2 diabetes: a randomized controlled trial.

Contrary to expectations from efficacy studies, this effectiveness trial does not support the metabolic benefits of oat-derived β-glucan-enriched bread under real-life conditions. A simple bread replacement may not be sufficient to improve glucose homeostasis in individuals at risk of type 2 diabetes. This trial was registered with clinicaltrials.gov as NCT04994327.

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Inflamm Bowel Dis

Evaluation and Management of Glucocorticoid-Induced Adrenal Insufficiency in IBD: An Expert Opinion.

GC-AI is a serious, often underrecognized side effect of glucocorticoid use. This study presents expert opinions on the evaluation and management of GC-AI in IBD patients, emphasizing the need for vigilance and appropriate management strategies.

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Fecal Calprotectin is a Useful Biomarker for Defining Small Bowel Endoscopic Remission in Crohn's Disease Without Active Colonic Lesions: A Prospective Multicenter Study from the IBD-Quality Team.

This study revealed a correlation between small bowel CE activity and FC. Under this condition, small bowel ER can be defined as an FC level of < 175 μg/g, and FC was suggested to be a useful biomarker for monitoring small bowel lesions during the application of treat-to-target strategies.

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Patients With Crohn's Disease and Terminal Ileum Resection are at Increased Risk of Colorectal Cancer: A Population-Based Study.

Patients with TI resection also had higher odds of colorectal polyps. These findings suggest the need for heightened CRC surveillance in patients with CD undergoing TI resection.

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Unraveling Genetic Versus Environmental Factors Determining Disease Course in Inflammatory Bowel Diseases: A Population-Based Cohort Study in First- and Second-Generation Immigrants.

Disease outcomes change across immigrant generations, pointing to environmental factors possibly impacting disease course, which needs further investigation. In contrast, non-Western immigrants were shown to have more perianal disease in both generations, suggesting a genetic susceptibility for this debilitating phenotype.

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Validation of the Modified Multiplier of SES-CD (MM-SES-CD) to Predict Endoscopic Healing in Crohn's Disease: A Post Hoc Analysis of the SEAVUE Trial.

Baseline MM-SES-CD-based cutoffs for endoscopic disease severity show prognostic value for the likelihood of achieving 1-year EH, PRO2 remission, and FCP remission. These findings suggest that the MM-SES-CD can be used both to measure baseline endoscopic disease severity and predict outcomes at 1 year in patients with moderate to severe CD.

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J Crohns Colitis

ECCO Topical Review on Pouch Disorders.

A multidisciplinary approach is essential for the diagnosis and management of pouch disorders.

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Endo-Histo foundational fusion model: a novel artificial intelligence for assessing histologic remission and response to therapy in ulcerative colitis clinical trial.

This novel tool significantly advances precision medicine in clinical trials by potentially standardizing central readouts and enabling automated disease assessment.

Pubmed   Journal   ReadQx   PMC

Gaps between European Crohn's and Colitis Organisation quality standards of care and the real world on diagnosis and monitoring inflammatory bowel disease across Europe: results from the E-QUALITY survey.

Significant gaps in QoC standards remain across European IBD units. Most units lack specific auditing mechanisms to track true standard compliance. Enhanced support from ECCO, through education on guidelines and implementation strategies, and adaptation of recommendations to accommodate real-world challenges may help to bridge these gaps.

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Impact of complete vs partial endoscopic healing on long-term outcomes in Crohn's disease: a prospective multicenter study.

Although higher-powered studies are needed to confirm these findings, current results suggest that complete EH may be associated with more favorable long-term outcomes than partial EH in patients with CD.

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The long-term disease course of microscopic colitis - a European prospective incident cohort study.

Microscopic colitis is a chronic condition with relapsing or continuous disease course in nearly half of the patients during the first 5 years after diagnosis. The disease course in the first year predicts the long-term disease course.

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Liver Transpl

Comparing donor selection barriers for living donor liver transplantation amongst hispanic and non-hispanic candidates in a large urban center.

LDLT disparities among Hispanics may involve factors preceding donor evaluation or independent of the donor. Optimizing Hispanic LLD candidacy, establishing a registry of individuals referred for LLD, and conducting multicenter studies are warranted.

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Management of hepatic artery thrombosis and stenosis after pediatric liver transplantation: Variability and agreement in management practices.

Internationally, there is agreement on the importance of early DUS screening in current management practices. Immediate re-transplantation was preferred for early HAT with PALF, while surgical revascularization was favored for non-PALF cases. Conservative management and endovascular therapy emerged as potential strategies for late-onset cases. This worldwide survey on real-world practice provides a basis for developing and implementing guidelines.

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Short- and long-term development of gut microbiota in children after liver transplantation - a prospective observational trial.

We provide comprehensive, quantitative insights into GM composition and function before and after pLT. A link between GM alterations with (long-term) graft health was uncovered providing possible targets to modulate GM function in order to increase graft and patient health.

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Pancreatology

Genome-wide discovery of enhancer - promoter interactions in the human pancreas using an improved Activity-By-Contact-based model.

We provide a genome-wide set of pancreas-specific enhancer regions and respective target genes. Our dataset will be helpful for the prioritization of regulatory disease-causing mutations in pancreatic tissue.

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Uric acid and related disorders in the risk of pancreatic diseases: A UK Biobank prospective study.

Our study clarifies the role of SUA in pancreatic health and identifies that individuals with HUA or gout may benefit from pancreatic disease screening.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

An Acute Onset Sweet Syndrome After First Vedolizumab Dose in Crohn's Disease.

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Efficacy and Safety of Upadacitinib in a Case of Pediatric Acute Severe Ulcerative Colitis and Immune Thrombocytopenia.

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Oral Vancomycin as an Emerging Therapy for Inflammatory Pouch Conditions Associated With Primary Sclerosing Cholangitis.

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Liver Transpl

Every last detail-Managing hepatic artery thrombosis and stenosis in a time of organ scarcity.

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Home-based terlipressin as a therapy for ascites: Increasing evidence for the efficacy of long-term continuous terlipressin infusion in decompensated cirrhosis.

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Normothermic machine perfusion - The juice is definitely worth the squeeze.

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Phosphatidylethanol and urinary ethylglucuronide to assess alcohol consumption after liver transplantation.

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Letters&Replies

Letters to the editors and authors’ replies

Pancreatology

Long-term survival and quality of life improvement in patients with large unresectable malignant main-duct IPMN treated with EUS-guided RFA (with video).

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